Available exclusively for Nintendo DS, Major League Baseball 2K8 Fantasy All-Stars offers fans of all ages a fun experience featuring starting lineups from all 30 Major League Baseball clubs, a variety of exhibition and tournament modes, All-Star training mini-games, along with fantasy-themed baseball stadiums.

Utilizing the functionality of the Nintendo DS touch screen, Major League Baseball 2K8 Fantasy All-Stars provides fans the unique opportunity to control the power and technique of their swings and the speed and accuracy of their pitch by performing specific gestures with the stylus. Fielding, baserunning and other controls also utilize the DS touch screen, as players drag and trace lines to execute these specific baseball actions.